Research

Research

Breast Cancer (BrCa) is a hormone-related malignancy. Current treatment plans target the hormone receptors, which also act as prognostic indicators. However, despite the advancement in treatment modalities, BrCa continues to be one of the most frequently diagnosed cancer in the world and the leading cause of cancer-related casualties in females. Accumulating evidence suggests that androgen signalling plays an important role in BrCa development and progression. With more than 60-80% of tumors expressing the Androgen Receptor (AR), the transcription factor has emerged as a potential prognostic marker and therapeutic target. We investigate the role of AR in the pathogenesis of BrCa using an integrated molecular approach. Our study aims to elucidate the role of AR as a probable therapeutic target in BrCa and help in understanding the genomic classification and characterization of BrCa amongst Indian women.

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